Alberto Cassetta Pagina Personale
Qualifica Attuale : Ricercatore.
Indirizzo ed Email :
Phone1:+39 040 375 7525 (Off.)
Phone2:+39 040 375 7521 / 7536 / 7537 (Lab.)
Phone3:+39 040 375 8355 (XRD-1 Beamline)
E-mail: alberto.cassettaATts.ic.cnr.it
Address: Istituto di Cristallografia – C.N.R. Sede Secondaria di Trieste,
Area Science Park – Basovizza
Edificio Q1, Stanza 104B
Strada Statale 14, Km. 163.5
I-34149 Trieste – Italy
Curriculum Vitae :
1990: Laurea diploma in Chemistry, Rome University “La Sapienza.
1990-92: Consultant at the Sincrotrone Trieste S.c.p.A, Scientific Division, Hard X – Ray Optics Group.
1992: Visiting Researcher at the Manchester University – Chemistry Department.
1992: Consultant at Sincrotrone Trieste S.c.p.A, Scientific Division , X – Ray Diffraction Beamline Group.
1992-2001: Contract Researcher at the Instituto di Strutturistica Chimica “G. Giacomello” (Montelibretti – Rome)
1995-96: European Community fellow at Manchester University – Chemistry Department.
1997-2010: Member of the XRD1 Beamline Team (GdR)
2000-2010: Technical coordinator of XRD1 Beamline (CNR designation)
2001 Researcher at Instituto di Strutturistica Chimica “G. Giacomello”, then Istituto di Cristallografia
Pubblicazioni Scelte :
S. Covaceuszach, M. Bozzi, M. G. Bigotti, F. Sciandra, P. V. Konarev, A. Brancaccio and A. Cassetta “The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan” PLoS ONE (2017) 12, e0186110
S. Covaceuszach, M. Bozzi, M. G. Bigotti, F. Sciandra, P. V. Konarev, A. Brancaccio and A. Cassetta “Structural flexibility of human α-dystroglycan” FEBS Open Bio (2017) 7, 1064-1077
A. Cassetta, J. Stojan I. Krastanova, K. Kristan, M. Brunskole Švegelj, D. Lamba, T. Lanišnik Rižner “Structural basis for inhibition of 17β”-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17β-HSDcl” J. Steroid Biochem Mol Bio (2017) 171, 80-93
M. Bozzi, A. Cassetta, S. Covaceuszach, M. G. Bigotti, S. Bannister, W. Hübner, F. Sciandra, D. Lamba, A. Brancaccio “The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight intothe Molecular Basis of a Primary Dystroglycanopathy” PLoS ONE (2015) 10, e0124277
A. Lausi,M. Polentarutti, S. Onesti, J. R. Plaisier,E. Busetto, G. Bais, L. Barba, A. Cassetta, G. Campi,D. Lamba, A. Pifferi, S. C. Mande, D. D. Sarma,S. M. Sharma, G. Paolucci “Status of the crystallographybeamlines at Elettra” Eur. Phys. J. Plus(2015) 130, 1
S.Covaceuszach, P. V. Konarev A. Cassetta, F. Paoletti, D. I. Svergun, D.Lamba, A. Cattaneo “The Conundrum of the High-Affinity NGF Binding SiteFormation Unveiled?” Biophys J. (2015) 108, 687
A. Cassetta,I. Krastanova, K. Kristan, M. Brunskole Švegelj, D. Lamba, T. Lanišnik Rižner, J.Stojan. “Insights into subtle conformational differences in thesubstrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structuraland kinetic approach” Biochem. J. (2012) 441, 151–160
Cassetta, A. Deacon, S. Ealick, J. R. Helliwell, A. Thompson. “Development of instrumentation and methods for MAD and structural genomics at the SRS, ESRF, CHESS and ELETTRA facilities.” J. Synchrotron Rad. . (1999), 6, 822
A.Hädener, P. K. Matzinger, A. R. Battersby, S. M. McSweeney, A. W. Thompson, A.P. Hammersley, S. J. Harrop, A. Cassetta, W. N. Hunter, Y. P. Nieh, J. R.Helliwell “Determination of the structure of selenomethionine-labelledhydroxymethylbilane synthase in itsc active form by multi-wawelenght anomalousdispersion” Acta Cryst. (1999) D55,631
N. E. Chayen, T. J. Boggon, A. Cassetta, A. Deacon, T. Gleichmann, J. Habash, S. J. Harrop, J. R. Helliwell, Y. P. Nieh, M. R. Peterson, J. Raftery, E. H. Snell, A. Hädener, A. C. Niemann, D. P. Siddons, V. Stojanoff, A. W. Thompson, T. Ursby, M. Wulff. “Trends and Challenges in Experimental Macromolecular Crystallography.” Q. Rev. Biophys. (1996), 29 (3), 227 – 278