Istituto di Cristallografia - CNR

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Doriano Lamba Pagina Personale

di · May 23, 2017

Doriano Lamba
Phone1: +39 040 375 7527 (Off.)
Phone2: +39 040 375 7521 / 7536 / 7537 (Lab.)
Phone3: +39 040 375 8355 (XRD-1 Beamline)
E-mail: doriano.lambaATts.ic.cnr.it / doriano.lambaATelettra.eu
Address: Istituto di Cristallografia – C.N.R. Sede Secondaria di Trieste,
Area Science Park – Basovizza
Edificio Q1, Stanza 106
Strada Statale 14, Km. 163.5
I-34149 Trieste – Italy

Present Qualification:
Senior Scientist

Curriculum Vitae :
1980: PhD in Chemistry cum laude, University of Rome “La Sapienza”, Roma, Italy
1985-1988: Postdoctoral Research Associate in Carbohydrate Chemistry, Astbury Department of Biophysics, University of Leeds, Leeds, UK
1993-1995: Postodoctoral Research Associate in Protein Crystallography, Abteilung für Strukturforschung, Max Planck Institut für Biochemie, Martinsried bei München, Germany
1983-1997: Scientist at IC-CNR, Monterotondo (Roma), Italy
1997-2005: Scientist at IC-CNR Trieste Outstation and XRD-1@ELETTRA Beamline scientist, Trieste, Italy
2003-2008: Member of the Steering Committee of IC-CNR
2005-2010: Team leader: Crystallography of Biomolecules and Functional Studies – Enabling Technologies for Drug Discovery, Molecular Design Dept., CNR
2006-Present:  Senior Scientist at IC-CNR Trieste Outstation,Trieste, Italy
2008-2010: Member of the Management Committee “Integrated Structural Biology Infrastructure for Europe”
2009-Present: Italian Delegate of the International Network Protein Engineering Centres                                                                              2010-2017: Deputy Head of the IC-CNR Trieste Outstation, Trieste, Italy
2010-2017: Adjunct professor “Structural Biology” – Scuola Normale Superiore di Pisa, Pisa, Italy
2012-2014: Elected Member of  the Computing & Instrumentation Commission of the Italian Crystallographic Association
2012-2014: Member, acting as President of the Italian Scientific Panel Review Committee – of the CRG GILDA beam line ESRF, Grenoble (France)
2013-Present: Member of the Steering Committee of CRG-IN13, ILL, Grenoble (France)
2015-Present: Member, acting as Scientific Secretary of the Italian Scientific Panel Review Committee – of the CRG LISA beam line –ESRF, Grenoble (France)
2016-Present: Elected  by the Italian Synchrotron Radiation Society as Italian Member-Delegate of the European Synchrotron User Organization (ESUO)
2017-Present: Adjunct professor “Synchrotron Radiation Applications in Structural Biology” – Università degli Studi di Trieste, Trieste, Italy
2017-Present: Elected member of the Special Interest Group “Biological Macromolecules” of the of the Italian Crystallographic Association
2017-Present: Member of the Executive Board of the Dep. of Chemical Science and Materials Technology, Consiglio Nazionale delle Ricerche

Research Activities:

  • Multitargeted directed ligands  for the treatment of Alzheimer’s Disease
  • Structural and functional studies of Neurotrophins and proNeurotrophins.
  • Structural and functional studies of neutralizing antibodies of therapeutic interest (anti Abeta oligomers).
  • Inter-kingdom molecular linguistics: Deciphering the structural basis of Quorum Sensing mechanisms

Selected Publications :

Web of Science Report (07.02.2018) Publications/Citations (1984-2018):
Total Publications: 113; H-index: 26; Average citations per item: 20.81; Sum of times cited: 2352; Sum of times cites without self-citations: 2270; Citing articles: 2094; Citing articles without self-citations: 2051

Relevant Publications (last 5 years):

1.Bhonsle J.B., Causey R., Oyler B.L., Bartolucci C., Lamba D., Pesaresi A., Bhamare N.K., Soojhawon I., Garcia G.E.“Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a  blood brain barrier model.” Chem. Biol. Interact. 203, 129-134 (2013)
2.Corbalan N., Runti G., Adler C., Covaceuszach S., Ford R., Lamba D., Beis K., Scocchi M.,  Vincent P.A. “Functional and structural study of the dimeric inner membrane protein SbmA.”J Bacteriology 195, 5352-5361 (2013)
3.Covaceuszach S., Degrassi G., Venturi V., Lamba D. “Structural insights on a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous quorum sensing LuxR-family.” Int. J. Mol. Sci. 14, 20578-20596 (2013)
4.Kumar Patel H., Ferrante P., Covaceuszach S., Lamba D., Scortichini M., Venturi V. “The kiwifruit emerging pathogen Pseudomonas syringae pv. actinidiae does not produce AHLs but possesses three LuxR solos.” PLoS ONE, 9, e87862 (2014)
5.Nepovimova E., Uliassi E., Korabecny J., Peña-Altamira L. , Samez S., Pesaresi A., Garcia G.E.,  Bartolini M., Andrisano V.,Bergamini C., Fato R., Lamba D., Roberti M., Kuca K., Monti B., Bolognesi M.L. “Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-beta aggregation and to exert anticholinesterase and antioxidant effects”  J. Med. Chem. 57, 8576–8589 (2014)
6.Paoletti F., Malerba F., Bruni E. P., Lamba D., Cattaneo A. “A comparative analysis of the structural, functional and biological differences between mouse and human nerve growth factor” Biochimica et  Biophysica Acta – Proteins and Proteomics 1854, 187-197 (2015)
7.Covaceuszach S., Konarev  P. V., Cassetta, A., Paoletti F., Svergun D.I., Lamba D., Cattaneo A. “The conundrum of the “high affinity” NGF binding sites formation unveiled?” Biophysical J.  108, 687-697 (2015)
8.Hudaiberdiev S., Choudhary S., Vera Alvarez R., Gelencsér Z., Ligeti B., Lamba D., Pongor S. “Census of solo LuxR genes in prokaryotic genomes” Front. Cell. Infect. Microbiol. 5, 20 (2015)
9.Lausi A., Polentarutti M., Onesti S., Plaisier J.R., Busetto E., Bais G., Barba L., Cassetta A., Campi G., Lamba D., Pifferi A., Mande S.C., Sarma D.D., Sharma S.M., Paolucci G. “Status of the crystallography beamlines at ELETTRA” Eur. Phys. J. Plus 130, 43 (2015)
10.Bozzi M., Cassetta A., Covaceuszach S.,  Bigotti M.G., Bannister S., Hübner W., Sciandra F., Lamba D.,  Brancaccio A. “The Structure of the T190M Mutant of Murine a-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy. PLos ONE 10, e0124277 (2015)
11.Passos da Silva D., Patel HK, González Paredes J.F., Devescovi G., Meng X., Covaceuszach S., Lamba D., Subramoni S.,Venturi V  “Studies on synthetic LuxR solo hybrids” Frontiers in Cellular and Infection Microbiology 5, 52 (2015)
12.Malerba, F.; Paoletti, F.; Bruni E.B.; Materazzi, S.; Nassini, R.; Coppi, E.; Patacchini, R.; Capsoni, S.; Lamba, D.; Cattaneo, A. “Functional characterization of human proNGF and NGF mutants: identification of NGF P61SR100E as a ‘painless’ lead investigational candidate for therapeutic applications” PLos ONE 10, e0136425 (2015)
13.Zha X., Lamba D., Zhang L., Lou Y., Zhou C., Xua C., Kang D., Chen L., Xu Y., Zhang L., De Simone A., Samez S., Pesaresi A., Stojan J., Garcia M., Egea J., Andrisano V., Bartolini M. “Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease:Design, Synthesis, Biological Evaluation and X-ray Crystallography” J. Med. Chem. 59, 114-131 (2016)
14.Paoletti F.,  De Chiara C., Kelly G., Covaceuszach S., Malerba F., Yan R., Lamba D., Cattaneo A., Pastore A. “Conformational rigidity within plasticity promotes differential target recognition of Nerve Growth Factor”. Frontiers in Molecular Biosciences 3,83 (2016)
15.Cassetta A., Stojan J., Krastanova I., Kristan K., Brunskole Švegelj M., Lamba D., Lanišnik Rižner T. “Structural basis for inhibition of 17β-hydroxysteroid dehydrogenases by phytoestrogens: the case of fungal 17β-HSDcl” The Journal of Steroid Biochemistry and Molecular Biology 171, 80-93 (2017)

Patent:
Cattaneo A., Covaceuszach S., Lamba D. “Method for the humanization of antibodies and humanized antibodies thereby obtained”. Patent WO/2005/061540