Revolutionizing Downstream Processing of Monoclonal Antibodies by Continuous Template–Assisted Membrane Crystallization (AMECRYS)


It is a research project funded under the Horizon 2020 programme, in the framework of Future and Emerging Technologies actions. H2020-FETOPEN-2014-2015/H2020-FETOPEN-2014-2015-RIA

Grant agreement n.712965

Funding for the Institute of Crystallography: 200674,00 €

Total budget of the project: 3533813,75 €


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The AMECRYS project aims to revolutionize the current industrial production processes of monoclonal antibodies (mAbs) by the production of continuous

 membrane crystallizers, capable of separating and purifying biological macromolecules directly into their culture broth. This will save about 60% of current mAbs production costs. The mAbs crystallization directly from a multi-component solution has never been realized and represents the most ambitious challenge that researchers will face during the project, starting with three strengths: the efficiency of technology-based crystallization technology of engineered membranes, the ability to induce selective crystallization through appropriately functional nanomaterials, the pharma-on-a-chip approach by means of microfluidic devices specially designed for continuous flow crystallization. This strategy will be supported by a detailed analysis of crystalline properties and intense computational effort to investigate the molecular mechanisms underlying the crystallization process and to study the relationship between the multiple experimental variables and the crystallization results.



National Research Council of Italy (CNR)

Institute on Membrane Technology (ITM)

Via P. Bucci, Cubo 17/C c/o Università  della Calabria

87036 Rende (CS), Italy

Tel.: +39 0984 492010/492014; Fax: +39 0984 402103



Responsible for the Institute of Crystallography: ROCCO CALIANDRO

National Research Council of Italy (CNR)

Institute of Crystallography (IC)

Via G, Amendola 122/o

70126 Bari (BA), Italy

Tel.: +39 0805929150; Fax: +39 0805929170