Author: crist2015capo

Mechanistic and structural basis for inhibition of copper trafficking by platinum anticancer drugs

Mechanistic and structural basis for inhibition of copper trafficking by platinum anticancer drugs

Only a few percent of the platinum (Pt)-based anticancer drugs reaches the nucleus and binds to DNA. The remaining part can interfere with copper (Cu) homeostasis and mediate cytotoxicity or resistance to chemotherapy. A...

MEPROT

MEPROT

 TITLE:  Role of Metal dyshomeostasis and ubiquitin-Proteasome system derangement in brain pathologies: risk factors and neuroprotective strategies MEPROT     FINANCING SCHEME:  PRIN: PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE – Bando 2015 Prot....

LEARNING FROM DIABETES TO TREAT ALZHEIMER’S DESEASE […]

LEARNING FROM DIABETES TO TREAT ALZHEIMER’S DESEASE […]

 TITLE:  Learning from diabetes to treat Alzheimer’s disease: a role for HSP60 in the regulation of brain IGF-I receptor signaling     FINANCING SCHEME:  SIR (Scientific Independence of young Researchers) 2014, funded by MIUR (Ministero...

THERMODYNAMICS AND ELECTROCHEMISTRY LABORATORY – IC CATANIA

THERMODYNAMICS AND ELECTROCHEMISTRY LABORATORY – IC CATANIA

 DESCRIPTION:  The thermodynamics and electrochemistry laboratory is equipped for structural and functional characterization studies on biomolecules. Isothermal Titration Calorimetry (ITC) and Differential Scanning Calorimetry (DSC) are powerful analytical techniques for in-depth characterization of molecular...

SPECTROSCOPY LABORATORY – IC CATANIA

SPECTROSCOPY LABORATORY – IC CATANIA

 DESCRIPTION:  The spectroscopy laboratory is dedicated to the biophysical characterization of macromolecules of biological interest. The instrumentation in use, associated with that of the thermodynamic laboratory, allows us to provide structural information  on the...

SPECTROMETRY LABORATORY – IC CATANIA

SPECTROMETRY LABORATORY – IC CATANIA

 DESCRIPTION:  The spectrometry laboratory is dedicated both to the characterization of molecules obtained by synthesis processes and to the analysis of biological samples. The high sensitivity of the mass spectrometers available in our laboratory,...

GARA PER ACQUISIZIONE DI STRUMENTAZIONE  – prot. IC-CNR n. 0001484 del 02/08/2019

GARA PER ACQUISIZIONE DI STRUMENTAZIONE – prot. IC-CNR n. 0001484 del 02/08/2019

(Available Only in  Italian) prot. IC-CNR n. 0001484 del 02/08/2019 PROCEDURA NEGOZIATA SENZA PREVIA PUBBLICAZIONE DI UN BANDO DI GARA (EX ART. 63, CO.2,LETT. B) PUNTO 2 DEL D.LGS. N. 50/2016) PER L’ACQUISIZIONE DI...

PEPTIDE SYNTHESIS LAB – IC CATANIA

PEPTIDE SYNTHESIS LAB – IC CATANIA

 DESCRIPTION:  The laboratory deals with the synthesis of peptides in solid phase with microwave technology, the conjugation of peptides with nanostructured systems and bioactive molecules, their analysis and purification. The synthesizers used in the...

PROTEIN EXPRESSION LABORATORY – IC CATANIA

PROTEIN EXPRESSION LABORATORY – IC CATANIA

 DESCRIPTION:  The Protein Expression laboratory contains all the facilities needed for the production of heterologous proteins from E. Coli or other appropriately engineered bacteria through the common molecular biology techniques. The growth of bacteria...

CELLULAR BIOLOGY LABORATORY – IC CATANIA

CELLULAR BIOLOGY LABORATORY – IC CATANIA

 DESCRIPTION:  The cellular biology laboratory allows investigations towards the understanding of the biology, biochemistry and signal trasduction at a cellular level. Both primary and secondary cells cultures are used. The behaviour of single cells...