X-ray synchrotron-class rotating anode microsource for the structural micro imaging of nanomaterials and enginereed biotissues



X-ray synchrotron-class rotating anode microsource for the structural micro imaging of nanomaterials and enginereed biotissues


Cinzia Giannini
Antonietta Guagliardi
Liberato De Caro
Massimo Ladisa
Giuseppe Chita
Rocco Lassandro
Davide Altamura *
[*] Personale non strutturato


Commessa:  PM.P04.011 / Diffrazione e imaging a raggi x per l'ingegneria di materiali nanostrutturati e tessuti biologici e per la biodiagnostica
Modulo: PM.P04.011.002 / Imaging a raggi X e algoritmi di ricostruzione della fase


imaging, nanocrystals, biomaterials

Dr. L. Manna, Istituto Italiano di Tecnologia, Genova
Dr. D.P. Cozzoli, National Nanotechnology Laboratory, Lecce
Dr. L. Curri, Dr. M. Striccoli, IPCF-CNR, Bari
Dr. Fabio Baruffaldi, Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli
Prof. Luisa Torsi, Dipartimento di Chimica, Università di Bari
Prof. Andrei Nikulin, Monash Univ., Australia

In the nanobulk age, which already predominates and more and more will dominate research on (bio)materials in the next 10-15 years, the benefits of nano- and biomaterials assembling to create useful macroscopic structures will be exploited. A smart material (nanostructured material or engineered tissue) no longer consist of simple nanoparticles, nanowires, or DNA strands, but rather of a complex bio-nano objects whose novel properties will depend on each of its (inorganic and biological) nano-components and their interaction. Realizing such structures strongly relies upon bottom-up approaches, through self-assembling of building blocks into macroscopic architectures. Self-assembled macroscopic architectures are hierarchical structures, characterized by a different order at different lenght scales. Also biological tissues as wood, bone, skin are hierarchical structures. Some of them are mineralized, forming for instance an organic/inorganic nanocomposite made of a fibrous matrix reinforced by crystalline or amorphous nanoparticles. Bones, teeth, horns, for instance, consist of a matrix of protein fibres (mainly collagen) reinforced by calcium phosphate nanocrystalline particles. The first step for in depth understanding of the function/structure relation, is a detailed structural characterization at all hierarchical levels. The aim of this project is to set up an X-Ray Micro Imaging Laboratory for structural, microstructural and morphological characterization of nanostructured materials and engineered tissues. Such laboratory will exploit a new synchrotron-class X-ray micro-source in the forefront at the national and international level, which suitably coupled to X-ray focusing optics will allow to perform: i) combined scanning Small Angle X-Ray Scattering (SAXS) and Wide Angle X-Ray Scattering (WAXS); ii) phase contrast imaging experiments. By means of the innovative synchrotron-class generators for X-ray high brilliance rotating anode micro-sources, all these high performance structural characterization techniques will no longer be a prerogative of synchrotron sources. The aim of the research activity is to gain access, by means of such instrumentation, to structural (atomic models), micro-structural (domain size and lattice strain) and morphological (domain shape) information from spatial regions of different extension (from millimetric to micrometric) of new nanostructured materials and bone biomaterials, whose functionality depends on the aforesaid structural properties. The combined use of such imaging techniques allows to obtain a map of micro/nano-structural characteristics of these spatially heterogeneous systems with the great advantage to provide quantitative structural information in a non-destructive manner.



Giannini Cinzia
Email : cinzia.gianniniATic.cnr.it
Tel : +39 080-5929167


Last Updated (Monday, 06 December 2010 10:38)