Sonia Covaceuszach

 

Sonia Covaceuszach


Sonia Covaceuszach

Phone1:+39 040 375 7526 (Off.)

Phone2:+39 040 375 7521 / 7536 / 7537 (Lab.)

E-mail: sonia.covaceuszachATts.ic.cnr.it

Address: Istituto di Cristallografia - C.N.R. Sede Secondaria di Trieste,

Area Science Park – Basovizza

Edificio Q1, Stanza 105B

Strada Statale 14, Km. 163.5

I-34149 Trieste – Italy

 

 

 

 

Present position :


- Staff Researcher

 

Short CV :

2012 Scientist at the IC-CNR Trieste Outstation, Trieste, Italy
2008-2011 Senior Scientist, Head of the Protein Science Area at Rottapharm Biotech Srl, Trieste, Italy
2006-2008 Scientist in the NGF Area at Lay Line Genomics SpA, Rome, Italy.
2004 Postodoctoral Fellowship at ETHZ, Zurich, Swizerland.
2002-2006 Postodoctoral Research Associate in the Neuroantibody Area at Lay Line Genomics SpA, Rome, Italy.
2002-2003 Postodoctoral Fellowship at IC-CNR, Monterotondo (Roma), Italy.
2002 PhD in Biophysics cum laude, SISSA/ISAS, Trieste, Italy.
1997 Degree in Biological Sciences cum laude, University of Trieste, Italy.

 

Research Activity :

- Structural and functional studies of neutralizing neuroantibodies of therapeutical interest (TrkA-receptor and Nerve Growth Factor)
- Design, development and functional studies on therapeutic antibodies in the fields of pain and osteoarthritis
- Structural and functional studies of Neurotrophins and proNeurotrophins
- Structural and functional studies of painless Nerve Growth Factor mutants

 

Selected publications :

Covaceuszach S., Capsoni S., Marinelli S., Pavone F., Ceci M., Ugolini G., Vignone D., Amato G., Paoletti F., Lamba D., Cattaneo, A. "In vitro receptor binding properties of a "painless" NGF mutein, linked to Hereditary Sensory Autonomic Neuropathy type V". Biochemical Biophysical Research Communications 391, 824-829 (2010).

Paoletti F., Covaceuszach S., Konarev P.V., Gonfloni S., Malerba F., Schwarz E., Svergun D.I., Cattaneo A., Lamba D. "Intrinsic structural disorder of mouse proNGF". Proteins, Structure, Function and Bioinformatics 75, 990-1009 (2009).

Covaceuszach S., Cassetta A., Konarev P. V., Gonfloni S., Ibañez C., Rudolph R., Svergun D.I., Lamba D., Cattaneo A. "Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody". Journal of Molecular. Biology 381, 881-896 (2008).

 

Ugolini G., Marinelli S., Covaceuszach S., Cattaneo A., Pavone F. "The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain." Proc Natl Acad Sci U S A. 104, 2985-2990 (2007).


Cattaneo A., Covaceuszach S., Lamba D. "Method for the humanization of antibodies and humanized antibodies thereby obtained". Patent WO/2005/061540.

 

Last Updated (Friday, 22 April 2016 14:14)