Michele Saviano

 

Michele Saviano - Direttore Istituto IC Michele Saviano
Tel. +39 080 5929148
Fax +39 080 5929170
E-mail : michele.savianoATic.cnr.it
Address :
Via Amendola 122/o - 70126 Bari

 

 

Present position :


- Director

 

 

Short CV :


From 1989 to 1992, CNR Researcher at the Centro di Studio di Biocristallografia (CNR), Naples.
From 1992 to 1998, Associated Researcher of Inorganic and General Chemistry at Faculty of Science of University of Naples "Federico II".
From 1998 Senior Researcher at Istituto di Biostrutture e Biommagini (IBB-CNR) Naples.
From May 2010 Director of Istitute of Crystallography (IC-CNR) Bari.

 

Research Interests:

The main interests lie in the field of peptide and protein chemistry. In particular, his studies include: a) de novo protein and peptide design; b) chemistry and conformational properties of peptides containing non natural amino acid residues; c) study of the preferred conformations of such amino acids in homo-oligo- peptides and model compounds in solution (by NMR, FT-IR, CD) and in the crystal state (by X-ray diffraction); d) rational design of conformationally constrained analogs of bioactive peptides with enhanced in vivo stability; e) development of computational procedures in the conformational analysis of bioactive molecules at different complexity; f) rational design of rigid peptide scaffolds for molecular recognition or intramolecular interaction; g) structural analysis of beta-cyclodextrins. He is author of about 170 full paper published on international journals, patents, and many lectures to national and international congresses.

 

Selected publications :

1. F Bellia, D La Mendola, C Pedone, E Rizzarelli, M Saviano, and G Vecchio. "Selectively functionalized cyclodextrins and their metal complexes." Chem Soc Rev. (2009) Sep; 38(9):2756-81
2. A Puglisi, E Rizzarelli, G Vecchio, R Iacovino, E Benedetti, C Pedone, and M Saviano "Crystal and molecular structure of beta-cyclodextrins functionalized with the anti-inflammatory drug Etodolac". Biopolymers (2009) Dec;91(12):1227-35.
3. Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M. A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): a study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus. Mol Biosyst. 2010 Oct 12.
4. Langella E, Pierre S, Ghattas W, Giorgi M, Reglier M, Saviano M, Esposito L, Hardre R. Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors. ChemMedChem. 2010 Sep 3;5(9):1568-76.
5. Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D'Auria S, De Simone G. Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125. Biopolymers. 2010 Aug;93(8):669-77.

 

 

Last Updated (Friday, 10 January 2014 15:49)