Sonia Covaceuszach Pagina Personale

Qualifica Attuale : Ricercatore.


Indirizzo ed Email : 

Telefono1:+39 040 375 7526 (Off.)

Telefono:+39 040 375 7521 / 7536 / 7537 (Lab.)


Indirizzo: Istituto di Cristallografia – C.N.R. Sede Secondaria di Trieste,

Area Science Park – Basovizza

Edificio Q1, Stanza 105B

Strada Statale 14, Km. 163.5

I-34149 Trieste – Italy


Curriculum Vitae :

2012 Ricercatore presso la sede secondaria di Trieste dell’Istituto di Cristallografia (CNR), Italia.
2008-2011 Ricercatore Senior, resposabile del settore di Protein Science presso Rottapharm Biotech Srl, Trieste, Italia.
2006-2008 Ricercatore nel settore NGF presso Lay Line Genomics SpA, Roma, Italia.
2004 Borsa Postdottorato  presso ETHZ, Zurigo, Svizzera.
2002-2006 Ricercatore nel settore dei Neuroanticorpi presso Lay Line Genomics SpA, Roma, Italia.
2002-2003 Borsa Postdottorato  presso la sede secondaria di la sede secondaria di Monterotondo (Roma) dell’Istituto di Cristallografia (CNR), Italia.
2002 PhD in Biofisica cum laude, SISSA/ISAS, Trieste, Italia.
1997 Laurea in Scienze Biologiche cum laude, Università di Trieste, Italia.


Attività di Ricerca :

– Structural and functional studies on dystoglycan and its pathological mutants associated to limb-girdle muscular dystrophy.
– Structural and functional studies of Neurotrophins and proNeurotrophins.

– Structural and functional studies of neutralizing neuroantibodies of therapeutical interest (anti Abeta oligomers).

–  Research activity on quorum sensing LuxR-type transcriptional regulators of bacterial pathogens,  involved in bacteria-bacteria and plant-pathogen interactions by interkingdom signalling circuits.


Pubblicazioni :

Signorino G, Covaceuszach S, Bozzi M, Hübner W, Mönkemöller V, Konarev PV, Cassetta A, Brancaccio A, Sciandra F. A dystroglycan mutation (p.Cys667Phe) associated to muscle-eye-brain disease with multicystic leucodystrophy results in ER-retention of the mutant protein. Hum Mutat. 2017 Nov 13. doi: 10.1002/humu.23370.

Covaceuszach S, Bozzi M, Bigotti MG, Sciandra F, Konarev PV, Brancaccio A, Cassetta A. “The effect of the pathological V72I, D109N and T190M missense mutations on the molecular structure of α-dystroglycan.” PLoS One. 2017 Oct 16;12(10):e0186110. doi: 10.1371/journal.pone.0186110. eCollection 2017.

Covaceuszach S., Bozzi M., Bigotti M.G. , Sciandra F., Konarev P., Brancaccio A., Cassetta A. Structural flexibility of human alpha-Dystroglycan. FEBS Open bio 7:1064 (2017), DOI: 1002/2211-5463.12259.

Devescovi G., Kojic M., Covaceuszach, Cámara M., Williams P., Bertani I., Subramoni S., Venturi V. Negative Regulation of Violacein Biosynthesis in Chromobacterium violaceum. Front Microbiol. 8:349 (2017).

Paoletti F., de Chiara C., Kelly G., Covaceuszach, Malerba F., Yan R., Lamba D., Cattaneo A., Pastore A. Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor. Front Mol Biosci. 3:83 (2016).

Passos da Silva D., Kumar Patel H.,González J.F., Devescovi G., Meng X., Covaceuszach S., Lamba D., Subramoni S., Venturi V. Studies on synthetic LuxR solo hybrids. Cell. Infect. Microbiol. 18;5:52 (2015).

Bozzi M., Cassetta A., Covaceuszach S., Bigotti M.G. , Bannister S., Hübner W., Sciandra F.,Lamba D., Brancaccio A. “The Structure of the T190M Mutant of Murine alpha-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy.” PLoS One 10(5):e0124277 (2015).

Covaceuszach S., Konarev P. V., Paoletti F., Krastanova I., Svergun D.I., Lamba D., Cattaneo A. “A novel molecular mechanism for the high affinity- p75-NGF-TrkA hetero complex formation: the role of NGF oligomers”. Biophysical J. 108(3):687 (2015).

Kumar Patel H., Ferrante P., Covaceuszach , Lamba D., Scortichini M., Venturi V. The kiwifruit emerging pathogen Pseudomonas syringae pv. actinidiae does not produce AHLs but possesses three LuxR solos. PLoS One 9(1):e87862 (2014).

Covaceuszach S., Degrassi G., Venturi V., Lamba D. “Structural insights on a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous LuxR-family.” International Journal of Molecular Science 14(10):20578 (2013).

Corbalan N., Runti G., Adler C., Covaceuszach S., Ford R., Lamba D., Beis K., Scocchi M., Vincent P.A. “Functional and structural study of the dimeric inner membrane protein SbmA.” J. Bacteriol. 195(23):5352 (2013).

Chiusaroli R., Visentini M., Galimberti C., Casseler C., Mennuni L., Covaceuszach S., Lanza M., Ugolini G., Caselli G., Rovati L.C., Visintin M. “Targeting of ADAMTS-5’s ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis.” Osteoarthritis and Cartilage (2013), Aug 15. doi:pii: S1063-4584(13)00919-9. 10.1016/j.joca.2013.08.015.

Covaceuszach S., Marinelli S., Krastanova I., Ugolini G., Pavone F., Lamba D., Cattaneo A. “Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody.” PLoS One 7(3):e32212 (2012).

Capsoni S., Covaceuszach S., Marinelli S., Ceci M., Bernardo A., Minghetti L., Ugolini G., Pavone F., Cattaneo A. Taking pain out of NGF: a “painless” NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One 28;6(2):e17321 (2011).

Covaceuszach S., Capsoni S., Marinelli S., Pavone F., Ceci M., Ugolini G., Vignone D., Amato G., Paoletti F., Lamba D., Cattaneo, A. “In vitro receptor binding properties of a “painless” NGF mutein, linked to Hereditary Sensory Autonomic Neuropathy type V”. Biochemical Biophysical Research Communications 391, 824-829 (2010).

Covaceuszach S., Capsoni S., Ugolini G., Spirito F., Vignone D., Cattaneo A. Development of a non invasive NGF-based therapy for Alzheimer’s disease. Curr Alzheimer Res. 6(2), 158-70 (2009).

Capsoni S., Covaceuszach S., Ugolini G., Spirito F., Vignone D., Stefanini B., Amato G., Cattaneo A. Delivery of NGF to the Brain: Intranasal versus Ocular Administration in Anti-NGF Transgenic Mice. J Alzheimers Dis. 16(2), 371-388 (2009).

Paoletti F., Covaceuszach S., Konarev P.V., Gonfloni S., Malerba F., Schwarz E., Svergun D.I., Cattaneo A., Lamba D. Intrinsic structural disorder of mouse proNGF. Proteins. 75(4), 990-1009 (2009).

Covaceuszach S., Cassetta A., Konarev P.V., Gonfloni. S., Rudolph R., Svergun D.I., Lamba D., Cattaneo A. Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J Mol Biol. 381(4), 881-9 (2008).

Ugolini G., Marinelli S., Covaceuszach S., Cattaneo A., Pavone F. The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain. Proc Natl Acad Sci U S A. Feb 20;104(8):2985-90 (2007).

Paoletti F., Konarev P. V., Covaceuszach S, Schwarz E., Cattaneo A., Lamba D., Svergun D. Structural and functional properties of mouse proNGF. Biochem Soc Trans. 34(4), 605-6 (2006).

Ugolini G., Covaceuszach S., Paoletti F., Visintin M., Lamba D., Cattaneo A. “Novel recombinant antibodies against AD biomarkers linked to neurotrophin signalling as potential diagnostic tools” Alzheimer & Dementia 2, S357 (2006).

Covaceuszach S., Cattaneo A., Lamba D. Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: A structural insight. Proteins 58(3), 717-727 (2005).

Brancucci A., Kuczewski N., Covaceuszach S., Cattaneo A., Domenici L. Nerve growth factor favours long-term depression over long-term potentiation in layer II-III neurones of rat visual cortex. J Physiol. 559, 497-506 (2004).

Covaceuszach S., Cassetta A., Cattaneo A., Lamba D. Purification, crystallization and X-ray diffraction analysis and phasing of a Fab fragment of monoclonal neuroantibody alphaD11 against nerve growth factor. Acta Crystallogr D Biol Crystallogr 60, 1323-1327 (2004).

Garaci E, Aquaro S, Lapenta C, Amendola A, Spada M, Covaceuszach S, Perno CF, Belardelli F. Anti-nerve growth factor Ab abrogates macrophage-mediated HIV-1 infection and depletion of CD4+ T lymphocytes in hu-SCID mice. PNAS 100, 8927-8932 (2003).

Tropea D., Capsoni S., Covaceuszach S., Domenici L., Cattaneo A. Rat visual cortical neurones express TrkA NGF receptor. Neuroreport 13, 1369-1373 (2002).

Margotti E., Covaceuszach S., Tongiorgi E., Cattaneo A., Domenici L. TRKB signalling controls the expression of N-methyl-d-aspartate receptors in the visual cortex. Eur J Neurosci 16, 1067-1074 (2002).

Covaceuszach S., Cattaneo A., Lamba D. Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti-tyrosine kinase A receptor monoclonal antibody. Acta Crystallogr D Biol Crystallogr 57, 1307-1309 (2001).

Mantovani F., Covaceuszach S., Rustighi A., Sgarra R., Heath C., Goodwin G.H. and Manfioletti G. Nf-kappaB mediated transcriptional activation is enhanced by the architectural factor HMGI-C. Nucleic Acid Research 26, 1433-1439 (1998).

Cattaneo A., Covaceuszach S., Lamba D. “Method for the humanization of antibodies and humanized antibodies thereby obtained”. Patent WO/2005/061540.