Michele Saviano Personal Page

Michele Saviano
Tel. +39 080 5929148
Fax +39 080 5929170
E-mail : michele.savianoATic.cnr.it
Address :
Via Amendola 122/o – 70126 Bari

Present position :
– Director

Short CV :

Director of Institute of Crystallography CNR -Bari from May 2010 to this date
Director di Research CNR, (Chemical Sciences), at Institute of Biostructures and Bioimaging CNR Napoli from January 2007 to this date
Senior Researcher CNR, at Institute of Biostructures and Bioimaging CNR Napoli from 1998 to 2006
Visiting Professor at Faculty of Sciences of University of Nancy “H. Poincaré”, Nancy France from 03/2000 to 05/2000 and from 05/2001 to 07/2001
Associated Researcher of Inorganic and General Chemistry at Faculty of Science of University of Naples “Federico II” from 1992 to 1998
Visiting Researcher at Gustaf H.Carlson School of Chemistry, Clark University, Worchester, Massachusetts, USA, from 1.06.1995 to 31.08.1995
Visiting Researcher at IBM Corporation “Scientific Engineering Computations Data Systems Division” in Kingston, New York, USA, from 09.1990 to 12.1990
Researcher CNR at the Centro di Studio di Biocristallografia (CNR) Napoli from 1989 to 1992

 

Research Interests:

The main interests lie interests lie in chemistry of bioactive systems: the relationships between structure and activity of numerous bioactive systems have been the object of his investigations, carried out with a variety of experimental and theoretical techniques, for the understanding of the mechanism of action of biologically relevant systems.
Recent Scientific Activities include: a) de novo protein, oligonucleotides and peptide design; b) rational design of conformationally constrained analogs of bioactive peptides with enhanced in vivo selectivity, affinity, and stability; c) development of computational procedures in the conformational analysis of bioactive molecules at different complexity; d) analysis with different computational techniques of modified oligonucleotides and their interaction with proteins or with DNA and RNA; d) chemistry and conformational properties of peptides containing non natural amino acid residues; e) study of the preferred conformations in solution (by NMR, FT-IR, CD) and in the crystal state (by X-ray diffraction) of bioactive molecular systems.
He is author of about 200 full paper published on international journals, patents, and many lectures to national and international congresses.

Extended CV

Saviano_curENG

 

Selected publications :

1. F Bellia, D La Mendola, C Pedone, E Rizzarelli, M Saviano, and G Vecchio. “Selectively functionalized cyclodextrins and their metal complexes.” Chem Soc Rev. (2009) Sep; 38(9):2756-81
2. A Puglisi, E Rizzarelli, G Vecchio, R Iacovino, E Benedetti, C Pedone, and M Saviano “Crystal and molecular structure of beta-cyclodextrins functionalized with the anti-inflammatory drug Etodolac”. Biopolymers (2009) Dec;91(12):1227-35.
3. Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M. A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): a study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus. Mol Biosyst. 2010 Oct 12.
4. Langella E, Pierre S, Ghattas W, Giorgi M, Reglier M, Saviano M, Esposito L, Hardre R. Probing the peptidylglycine alpha-hydroxylating monooxygenase active site with novel 4-phenyl-3-butenoic acid based inhibitors. ChemMedChem. 2010 Sep 3;5(9):1568-76.
5. Alterio V, Aurilia V, Romanelli A, Parracino A, Saviano M, D’Auria S, De Simone G. Crystal structure of an S-formylglutathione hydrolase from Pseudoalteromonas haloplanktis TAC125. Biopolymers. 2010 Aug;93(8):669-77.