(Italiano) Istituto di Cristallografia - CNR

(Italiano) Sito web ufficiale dell'Istituto di Cristallografia del Consiglio Nazionale delle ricerche

Carmelo Giacovazzo Personal Page

by · December 19, 2017

CARMELO GIACOVAZZO

E-mail : carmelo.giacovazzoATic.cnr.it
Address : CNR – Institute of Crystallography, Via Amendola 122/o – 70126 Bari
Affiliation: Università degli Studi di Bari “Aldo Moro” (Dipartimento Geomineralogico della Facoltà di Scienze).
Position : Associate

 

Short CV :

Please insert here

Full professor of Crystallography at  Bari University from 1975 up to retirement.

From 1993  up to 2008 , Director of Istituto di Cristallografia,  CNR

 

Research Activity :

Scientific papers. 329 articles on international journals.

Books

1- Direct Methods in Crystallography, Academic Press, London, 1980,  C. Giacovazzo.

2- Introduzione alla Cristallografia Moderna, Fratelli Laterza  Publisher, Bari, 1985,

Edited by  C. Giacovazzo; Authors: M. Bolognesi, A. Coda, C. Giacovazzo, G. Gilli, F. Scordari & D. Viterbo.

3- Fundamentals of Crystallography, Oxford University Press, 1992.  Edited  by  C. Giacovazzo; Authors: C. Giacovazzo, H.L. Monaco, D. Viterbo, F. Scordari, G. Gilli, G. Zanotti & M. Catti.
4- Direct Phasing in Crystallopraphy: Fundamentals and Applications, Oxford University Press, London, 1998, Author: C. Giacovazzo.
5- Fundamentals of Crystallography – Second Edition, Oxford University Press, 2002.  Edited by  C. Giacovazzo; Authors: C. Giacovazzo, H.L. Monaco, G. Artioli, D. Viterbo, G. Ferraris, G. Gilli, G. Zanotti & M. Catti.

6- Phasing in Crystallography: A Modern Perspective. Author : C. Giacovazzo. Oxford University Press, London , 2014

Public offices

President of  Associazione Italiana di Cristallografia from 1982 to 1984.

President of the  European Crystallographic Association from 1997 to 2000

Editor of  Acta Crystallographica A and Zeitschrift fur Kristallographie

International prizes
European Italgas Prize for  research and innovation, 1996
Max Perutz Prize, European Crystallographic Association, 2003

Peter Ewald Prize, International Union of Crystallography, 2011

European Powder Diffraction Society  Prize, 2016.

50th anniversary  Prize of  the Italian Crystallographic Association, Perugia 2017

 Research activity

Research activity  has been mostly dedicated to the solution of the phase problem in crystallography. The most relevant results may be described as follows:

  1. development of the structure invariant and seminvariant theory. The representation theory , one of the achievements, has been explicitly quoted in the Nobel Lecture by Herbert Hauptman (1985) who contributed to the problem by the related neighbourhood theory: “The methods for identifying the neighbourhoods of the structure seminvariants were developed indipendently and simultaneously by Giacovazzo and Hauptman. The former used the theory of representation in a very general setting; the latter used the extension concept to work through the details in a number of special cases, which were, however, representative. Although the methods differ in detail, they appear to be mathematically equivalent”.
  2.  The theories in 1) were implemented in software packages for crystal structure determination  of small-medium molecules ( up to 200 non-H  atoms in the asymmetric unit). Presently more than 600 laboratories in the world use such packages ( the SIR suite)..
  3.  Often crystal specimens of sufficient size are not available, but ony crystalline power may be used. A software package has been developed for the crystal structure solution  via powder data  (SIRPOW.92 and  EXPO) . the package is used in more than 350 laboratories.
  4.  new theories for improving molecular replacement techniques, the method of isomorphous derivatives and  anomalous dispersion approaches  have been developed. Such theories were implemented in software packages  and distributed to the crystallographic community..
  5.  A probabilistic theory describing the behavior and the properties of the reflection with rational indices has been settled. The theory has been coupled with a new phasing approach, the confinement method, which may be used when diffuse scattering from  single object is available.

Selected Publications :

  1. M. C. Burla, G. L. Cascarano, C. Giacovazzoand G. Polidori (2017). . The phantom derivative method when a structure model is available: about its theoretical basis. Acta Cryst.. A73, 218-226

2 . M. C. Burla, B. Carrozzini, G. L. Cascarano, C. Giacovazzo and G. Polidori (2017). . About difference electron densities and their properties. . Acta Cryst. . A73, 460-473
3.  R. Caliandro, B. Carrozzini, G. L. Cascarano, L. De Caro, C. Giacovazzo and D. Siliqi (2005).  Phasing at resolution higher than the experimental resolution. Acta Cryst.. D61, 556-565
4. C. Giacovazzo (2015). . Solution of the phase problem at non-atomic resolution by the phantom derivative method.  Acta Cryst.  A71, 483-512
5. C. Giacovazzo and A. Mazzone (2012). . A practical study of the electron-density-map variance. Acta Cryst. . A68, 464-469
6. R. Caliandro, B. Carrozzini, G. L. Cascarano, C. Giacovazzo, A. Mazzone and D. Siliqi (2009).  Molecular replacement: the probabilistic approach of the program REMO09 and its applications. Acta Cryst. . A65, 512-527
7. M. C. Burla, G. L. Cascarano, C. Giacovazzo and G. Polidori (2017). . Synergy among phase-refinement techniques in macromolecular crystallography.  Acta Cryst.  D73, 877-888
8. R. Caliandro, B. Carrozzini, G. L. Cascarano, L. De Caro, C. Giacovazzo and D. Siliqi (2005).  Phasing at resolution higher than the experimental resolution.  Acta Cryst.  D61, 556-565