Neuroprotective Effect of Carnosine Is Mediated by Insulin-Degrading Enzyme
L-Carnosine is an endogenous dipeptide that has high potential for therapeutic purposes, being an antioxidant with metal chelating, anti-aggregating, anti-inflammatory, and neuroprotective properties. Despite its potential therapeutic values, the biomolecular mechanisms involved in neuroprotection are not fully understood. Here, we demonstrate, at chemical and biochemical levels, that insulin-degrading enzyme plays a pivotal role in carnosine neuroprotection.
| Year |
|---|
| 2022 |
| Journal |
| ACS chemical neuroscience |
Impact factor
5.780
RESEARCH AREA
KEYWORDS
Authors
Distefano, Alessia; Caruso, Giuseppe; Oliveri, Valentina; Bellia, Francesco; Sbardella, Diego; Zingale, Gabriele Antonio; Caraci, Filippo; Grasso, Giuseppe
Authors IC CNR
