Institute of Crystallography - CNR

Tomasello Marianna Flora



Marianna F. Tomasello was trained in biological sciences at the University of Catania, obtaining her graduation with Honors (cum laude) in 2001, working on the mitochondria and apoptosis. She joined the team of Pr. Mazat at INSERM Bordeaux (France) in the framework of the ERASMUS program where she was introduced to the use of fluorescence technologies, including confocal and wide field epifluorescence microscopy and cytofluorimetry. Shortly after the graduation she went back to Bordeaux, as Dr. F. Ichas offered her to spend a year in his lab to carry on a short-term industrial (UCB-Pharma) research project as research assistant. After the successful completion of this program, she registered for a voluntary PhD at the University of Catania (Italy) under the supervision of Prof. V. De Pinto and continued to regularly interact with the Ichas group during the PhD, supported by a bilateral France-Italy GALILEO program, awarded to her. She was also awarded a French “EGIDE” fellowship for the completion of her PhD thesis in Bordeaux. The project she developed in her PhD thesis concerned the study of the molecular mechanisms of apoptotic cell death.

In 2005 she was appointed for a two-year postdoctoral position at the CEA (commissariat a l’energie Atomique) in Gif Sur Yvette (France) to work within the Prof. M. Toledano and Prof J.Drapier teams. The project she developed concerned the cellular metabolism of oxygen and reactive oxygen species (ROS) acting on cysteine residues and their significance in aging and cancer.

In 2008 she joined the Sonja Vermeren team at the Babraham Institute in Cambridge (United Kingdom) to fill a vacancy as Research Assistant, where she was involved in the study of a small GTPase called ARAP3 in the regulation of cell migration and chemotaxix.

Her stay, planned for a year, lasted only six months as she was offered to come back to Italy under a “ricercatore di chiara fama” contract, at the CNRIBB UOS under the supervision of Dr. G. Pappalardo. In 2009 she was admitted to the international PhD program in Neuropharmacology at Catania University, under the supervision of Prof A. Copani. She obtained her Neuropharmacology PhD in 2012 defending a thesis concerning the role of Amiloid beta peptide in the development of Alzheimer disease. Since then, she has been working in the field of neurosciences. Since December 2018 she has a permanent position as researcher of the National Research Council (CNR).

Carrying on her research career, she was also involved in teaching Molecular Biology and Fluorescence-based analytical methodologies at the CNRIBB and University of Catania, and she has supervised undergraduate and PhD students.

Topics: Life Science, Apoptotis, Mitochondria, Signal Transduction, Neurobiology, Oxidative stress, Cancer.

Techniques: Cellular and Molecular Biology, Biochemistry, Imaging, Flow Cytometry, Fluorescence, HTS, HCS.

Established long-standing cooperation with several outstanding groups, as witnessed by the scientific production: V. DePinto (unict), E. Rizzarelli (unict), A. Copani (unict), G. Lazzarino (unict), D. Fregona (unipd), PV. Piazza (INSERM), L. Bepoldin (CNRS), C. Satriano (unict), N. Micali (CNR), C. Martini (unipi). F. Nicoletti (uniroma),

Molecular Connections between DNA Replication and Cell Death in ?-Amyloid-Treated Neurons

Filippo Caraci , Annamaria Fidilio, Rosa Santangelo, Giuseppe Caruso, Maria Laura Giuffrida, Marianna Flora Tomasello, Ferdinando Nicoletti, Agata Copani.

Current neuropharmacology (2023)

Voltage Dependent Anion Channel 3 (VDAC3) protects mitochondria from oxidative stress

Reina, Simona and Nibali, Stefano Conti and Tomasello, Marianna Flora and Magri, Andrea and Messina, Angela and De Pinto, Vito

RedoxBiology (2022)

Beta-amyloid monomers drive up neuronal aerobic glycolysis in response to energy stressors

Santangelo R.; Giuffrida M.L.; Satriano C.; Tomasello M.F.; Zimbone S.; Copani A.

Aging (Albany, N.Y. Online) (2021)

Small hexokinase 1 peptide against toxic sod1 g93a mitochondrial accumulation in als rescues the atp-related respiration

Magr?, A. and Risiglione, P. and Caccamo, A. and Formicola, B. and Tomasello, M.F. and Arrigoni, C. and Zimbone, S. and Guarino, F. and Re, F. and Messina, A.

Biomedicines (2021)

The pleiotropic potential of bdnf beyond neurons: Implication for a healthy mind in a healthy body

Di Rosa M.C.; Zimbone S.; Saab M.W.; Tomasello M.F.

Life (Basel) (2021)