We examined the reaction of hydroxyl radicals (HOo) and sulfate radical anions (SO4o-), which is generated by ionizing radiation in aqueous solutions under anoxic conditions, with an alternating GC doubled-stranded...
Microcalcifications, small deposits of calcium-containing minerals that form in breast tissue, are often, but not always, a warning sign of breast cancer. The relationship between microcalcifications and cancer has not...
The development of small molecules that selectively target the cannabinoid receptor subtype 2 (CB2R) is emerging as an intriguing therapeutic strategy to treat neurodegeneration, as well as to contrast the...
The development of effective drugs to treat coronavirus infections remains a significant challenge for the scientific community. Recent evidence reports on the sigma-1 receptor (S1R) as a key druggable host...
GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design
This study introduces a new de novo design algorithm called GENERA that combines the capabilities of a deep-learning algorithm for automated drug-like analogue design, called DeLA-Drug, with a genetic algorithm...
Flexible perovskite solar cells are lightweight, bendable, and applicable to curved surfaces. Polyethylene terephthalate (PET) has become the substrate of choice compared to other plastic substrates like polyethylene naphthalate. PET...
Joint workshop between researchers from IC and Ivodent Academy (Tirana, Albania), with focus on materials and methodologies developed from both the institutions for biomedical applications
HMGA proteins are intrinsically disordered (ID) chromatin architectural factors characterized by three DNA binding domains (AT-hooks) that allow them to bind into the DNA minor groove of AT-rich stretches. HMGA...
The review considers various aspects of the influence of the glycolytic enzyme, sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDS) on the energy metabolism of spermatozoa and on the occurrence of several pathologies both...
Immunotherapy is among the most effective approaches for treating cancer. One of the key aspects for successful immunotherapy is to achieve a strong and stable antitumor immune response. Modern immune...
