PPARgamma represents a key target for the treatment of type 2 diabetes and metabolic syndrome. To avoid serious adverse effects related to the PPARgamma agonism profile of traditional antidiabetic drugs,...
On a sample of the Turin Shroud (TS), we applied a new method for dating ancient linen threads by inspecting their structural degradation by means of Wide-Angle X-ray Scattering (WAXS).
This project proposal has been conceived and prepared by a group of 8 partners, 6 research organisations and two companies, with an extensive track record of research activities in the...
Introduction Calix[n]arenes are a family of phenolic-based macrocycles of great interest for their synthetic versatility and ability to self-assembly in nanostructured systems. In the search for novel antibacterial agents, we...
Background: Ectopic cell cycle reactivation in neurons is associated with neuronal death in Alzheimer's disease. In cultured rodent neurons, synthetic ?-amyloid (A?) reproduces the neuronal cell cycle re-entry observed in...
In addition to its remarkable genome editing capability, the CRISPR-Cas system has proven to be very effective in many fields of application, including the biosensing of pathogenic infections, mutagenic defects,...
Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease affecting spinal cord motor...
CrystalMELA: a new crystallographic machine learning platform for crystal system determination
Genomics, structural engineering and chemical-physical characterization for biology and biotechnology
Perfluorooctanoic acid (PFOA) is a toxic compound that is absorbed and distributed throughout the body by noncovalent binding to serum proteins such as human serum albumin (hSA). Though the interaction...
