The present proposal envisages the investigation of the potentiality of REBCO high temperature superconductors (HTS) in high field (10 - 18 T) and low temperature (< 20 - 30 K)...
Cu homeostasis is primarily regulated by soluble and membrane transporters that exchange the metal ion between the cytosolic and extracellular compartments, in order to maintain the concentration in a narrow...
Mechanistic enzymology of pharmacological targets by means of crystallographic, computational and kinetic techniques
Molecular dynamics simulations of biological macromolecules aimed at: i) getting insights into their dynamic properties; ii) identifying the conformational/functional effect of point mutations responsible for genetic diseases.
Application of structure- and ligand- based methodologies for the development of models able to predict the bioactivity/toxicity of small molecules. The ultimate aim is that of providing clues for the...
Development, validation and application of machine learning and deep learning algorithms for the automated generation (de-novo design) of bioactive compounds.
Structural and functional characterization of neurotrophins, proneurotrophins and their pathological mutants. Structural studies of the role of endogenous biomolecules as modulators of neurotrophins and proneurotrophins.
Structural characterization of extracellular matrix proteins (amino-terminal domain of alpha dystroglycan, beta dystroglycan and LG1-2 domains of agrin) and their pathological mutants.
Structural and functional characterization of the main mediators of quorum sensing (LuxRs) and of the structural basis of their specificity vs promiscuity towards different autoinducers. Structural studies on the role...
Shwachman-Diamond syndrome is a rare disease that from a molecular point of view belongs to a class of diseases known as ribosomopathies. The two most involved proteins are SBDS and...
