Institute of Crystallography - CNR

Pascucci Barbara


I graduated in 1993 at the University of Rome “La Sapienza” discussing an experimental thesis entitled “Production and characterization of recombinant human Factor XII proteins lacking specific structural domains”. In the two years of experimental work I had the opportunity to learn the techniques of molecular and cellular biology but above all the enthusiasm as well as the scientific rigor necessary to carry out the research activity.

After graduating I began to be interested in the molecular mechanisms of mutagenesis and DNA repair, using both cellular systems and purified proteins, carrying out research at the Istituto Superiore di Sanità.

In recent years I have been involved in studies on the effect of nanoparticles on the bone differentiation process in microgravity conditions, both real and simulated.

Currently my scientific/experimental work is aimed at:

  • to analyze the role of oxidative stress, the response to oxidative damage and mitochondrial function in modulating the risk of chronic-degenerative diseases
  • to identify new biomarkers of exposure/effect/susceptibility

Over the years I have stayed abroad, for various periods, to carry out projects in collaboration with researchers from various international institutions:

-Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam.

-Cancérogenese et Mutagenése Moleculaire et Structurale, Unité Prope de Recherche du Centre National de la Recherche Scientifique – CNRS, Strasbourg.

-Laboratory Epidemiologie Moléculaire du Cancer – CNRS, Institut de Recherche Contre le Cancer de l’Appareil Digestif – IRCAD, Strasbourg.

-Institut fur Veterinarbiochemie, University of Zurich.

–NASA laboratories of Kennedy Space Center, Cape Canaveral.


See the attached CV for a more complete picture.

Molecular and cellular biology techniques


The most recent and current collaborations are with researchers from the Istituto Superiore di Sanità, the University of Pavia, the University of Milan and the ISOF-CNR.

Effects of Oxygen Tension for Membrane Lipidome Remodeling of Cockayne Syndrome Cell Models

Carla Ferreri 1, Anna Sansone 1, Annalisa Masi 1,2, Barbara Pascucci 2,3, Mariarosaria D’Errico 3, Marios G. Krokidis 4 and Chryssostomos Chatgilialoglu 1,5,*

Cells (2022)

Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted

Giulia Montagna1 · Giuseppe Pani2 · Dani Flinkman3,4 · Francesco Cristofaro1 · Barbara Pascucci5 · Luca Massimino6 · Luigi Antonio Lamparelli6 · Lorenzo Fassina7 · Peter James3,4 · Eleanor Coffey3 · Giuseppina Rea5 · Livia Visai1,8 · Angela Maria Rizzo2

Cellular and molecular life sciences (Electron. ed.) (2022)

Assessing the Formation of Purine Lesions in Mitochondrial DNA of Cockayne Syndrome Cells

Chryssostomos Chatgilialoglu 1,2, Marios G. Krokidis 3, Annalisa Masi 4, Sebastian Barata-Vallejo 1,5, Carla Ferreri 1, Barbara Pascucci 4,6, Mariarosaria D’Errico 6

Biomolecules (2022)

Cockayne syndrome: a DNA repair defective syndrome with neurodegenerative features

Barbara Pascucci, Mariarosaria D’Errico


DRP1 Inhibition Rescues Mitochondrial Integrity and Excessive Apoptosis in CS-A Disease Cell Models

Pascucci B, Spadaro F, Pietraforte D, De Nuccio C, Visentin S, Giglio P, Dogliotti E and D’Errico M.

International journal of molecular sciences (Online) (2021)

The interplay between mitochondrial functionality and genome integrity in the prevention of human neurologic diseases

D’Errico M.; Parlanti E.; Pascucci B.; Filomeni G.; Mastroberardino P.G.; Dogliotti E.

Archives of biochemistry and biophysics (Print) (2021)