The rationale of the present project is that is possible to mimic the orientation and the interactions of the key residues of a protein motif by varying the position and...
This proposal sets its foundations on a multidisciplinary research team with strong expertise in biochemistry, dermatology, microbiology, nanomaterial engineering, physical-chemistry. All the required competences are therefore present to unlock the...
Uveal Melanoma (UM) is a rare form of melanoma but the most frequent and aggressive primary ocular tumor in adults with about 50% of patients developing metastasis with fatal outcome...
Lafora disease (LD) is a progressive and fatal epilepsy with teenage-onset. It is caused by the accumulation of insoluble polyglucosans in neurons, determined by an increased glycogen production. At the...
The pressure-induced properties of hybrid organic-inorganic ferroelectrics (HOIFs) with tunable structures and selectable organic and inorganic components are important for device fabrication. However, given the structural complexity of polycrystalline HOIFs...
Hexokinase (HK) is the first enzyme of glycolytic pathway and traps glucose inside the cell as 6Pi-glucose. To conveniently access ATP necessary for phosphorylation, HK binds on the surface of...
Many apparently unrelated pathologies termed as “protein conformational diseases” (PCDs), including Alzheimer’s (AD), Parkinson (PD) and prion diseases, are characterized by abnormal accumulation of misfolded, toxic proteins. A hallmark of...
Type I mucopolysaccharidosis (MPS I) is caused by mutations of the lysosomal glycosidase α-L-iduronidase (IDUA) gene and functional deficiency of the IDUA (E.C. 3.2.1.76) (Hampe et al. 2020). The enzymatic...
Research Units The project will be carried out by the following research units (RU): • RU1, coordinated by the PI (Dr. Mangiatordi) and located at the Institute of Crystallography of...
Il progetto BIO-DUST mira alla produzione di un nuovo prodotto green, a partire da scarti, per la stampa 3D di pezzi mancanti di statue e nella creazione di copie di...
