Institute of Crystallography - CNR

Sciacca Michele Francesco Maria


He got Bachelor Degree in Industrial Chemistry at University of Catania in 2004 defending the thesis “Molecular interpretation of conformational diseases: Chemical-physics of the interactions amylin-membrane”. He started a research collaboration with the Department of Chemistry of the University of Catania working on thermodynamic of biological systems, and in particular on the proteins folding/unfolding mechanisms and the protein/membrane interactions.

In 2009 he got Ph.D. in Chemical Science at University of Catania, defending the thesis “Molecular mechanisms of protein misfolding diseases” and then started a scientific collaboration with the Institute of Biostructures and Bioimages of National Research Council, focusing his research activity on the effect of metal cations in modulating protein/membrane interaction and fibril formation mechanism of amyloidogenic proteins.

In 2011 he was Postdoctoral Fellows at University of Michigan, Ann Arbor, MI (USA) in the LSA Biophysics and Department of Chemistry, in the research group directed by Prof. A. Ramamoorthy. In the U.S. he focused his study on the molecular details underlying conformational diseases and on the mechanisms of action of antimicrobial peptides. In particular he studied the influence of lipidic composition in the protein/membrane interactions.

Back in Italy in 2013 he started a scientific collaboration with the Department of Chemical Science at University of Catania and then with the National Research Council – Institute of Biostructures and Bioimaging then merged into the Institute of Crystallography. Here he studies peptides and small natural compounds as inhibitors of toxicity and fibrillogenesis of amyloidogenic proteins. From July 2020 he is permanent research at National Research Council – Institute of Crystallography in  Catania.

Spectroscopic techniques:  Spectrofluorimetry, UV-vis. Spectroscopy, Circular Dichroism;

Calorimetric techniques: Differential Scanning Calorimetry, Pressure Perturbation Calorimetry and Isothermal Titration Calorimetry

Preparation and chemico-physical characterization of complex lipidic model membranes

Expertise in the study of molecular processes involved in the peptide/model membranes interaction

Prof. Ayyalusamy Ramamoorthy – University of Michigan

Prof. Carmelo La Rosa – University of Catania

Prof. Giovanni Di Fabio – University of Naples Federico II

The A?8-20 fragment as anti-fibrillogenic and neuroprotective agent: advancing towards efficient Alzheimer’s disease treatment

Stefania Zimbone, Maria Laura Giuffrida, Giuseppina Sabatino, Giuseppe Di Natale, Rita Tosto, Grazia M. L. Consoli, Danilo Milardi, Giuseppe Pappalardo, Michele F.M. Sciacca

ACS chemical neuroscience (2023)

GxxxG motif stabilize ion-channel like pores through C?-H???OH interaction in a?(1-40)

C. Rando, G. Grasso, D. Sarkar, M.F.M. Sciacca, L.M. Cucci, A. Cosentino, G. Forte, M. Pannuzzo, C. Satriano, A. Bhunia, C. La Rosa

International journal of molecular sciences (Online) (2023)

Stretching the chains: the destabilizing impact of Cu2+ and Zn2+ ions on K48-linked diubiquitin

Mangini, Vincenzo; Grasso, Giulia; Belviso, Benny Danilo; Sciacca, Michele F. M.; Lanza, Valeria; Caliandro, Rocco; Milardi, Danilo

Dalton transactions (2003. Print) (2023)

Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models

Sciacca M.F.M.; Naletova I.; Giuffrida M.L.; Attanasio F.

ACS chemical neuroscience (2022)

A? and Tau Interact with Metal Ions, Lipid Membranes and Peptide-Based Amyloid Inhibitors: Are These Common Features Relevant in Alzheimer’s Disease?

Giuseppe Di Natale, Giuseppina Sabatino ,Michele Francesco Maria Sciacca ,Rita Tosto, Danilo Milardi and Giuseppe Pappalardo

Molecules (Basel, Online) (2022)

Tau/A? chimera peptides: A Thioflavin-T and MALDI-TOF study of A? amyloidosis in the presence of Cu(II) or Zn(II) ions and total lipid brain extract (TLBE) vesicles

Sciacca M.F.M.; Di Natale G.; Milardi D.; Pappalardo G.

Chemistry and physics of lipids (Print) (2021)

Probing the helical stability in a VEGF-mimetic peptide

De Rosa L.; Diana D.; Di Stasi R.; Romanelli A.; Sciacca M.F.M.; Milardi D.; Isernia C.; Fattorusso R.; D’Andrea L.D.

Bioorganic chemistry (Print) (2021)

The interplay between lipid and A? amyloid homeostasis in Alzheimer’s Disease: risk factors and therapeutic opportunities

Garcia-Vinuales S.; Sciacca M.F.M.; Lanza V.; Santoro A.M.; Grasso G.; Tundo G.R.; Sbardella D.; Coletta M.; Grasso G.; La Rosa C.; Milardi D.

Chemistry and physics of lipids (Print) (2021)