Il laboratorio è provvisto di strumentazioni avanzate per la cristallizzazione di proteine (solubili e di membrana) e per la caratterizzazione di campioni biologici e nanomateriali finalizzati all'analisi strutturale. E’...
A) ITACA.SB High Performance Computing (HPC): the HERMES facility and its application to AI-driven de novo drug design (ALCHIMIA) Within the ITACA.SB infrastructure, HERMES is a GPU-accelerated High Performance Computing...
Venue Polytechnic University, Campus, Via E. Orabona, 4 - Bari Aims and Target Audience The event is jointly organized by the Institute of Crystallography (IC) of the National Research Council...
Mapping Amyloid-β post-translational modifications across deposits in Alzheimer’s disease: a neuropathological and functional analysis of nitration. Alzheimer’s disease is characterized by the accumulation of amyloid-β (Aβ) deposits that differ in...
The reaction of the HS•/S•− radical (pKa ~3.4), generated selectively from H2S by γ-irradiated N2-flushed aqueous solutions at pH 5, with purine nucleosides (dG or dA), a 10-mer double-stranded oligodeoxynucleotide...
This work reports the development and analytical validation of FACILE 2.0, a portable multifunctional potentiostat designed for electrochemical measurements under both static and microfluidic configurations. The platform integrates a compact...
Microalgae represent some of the most promising eukaryotic platforms in biotechnology due to their rapid growth, simple cultivation requirements, reliance on sunlight as a primary energy source, and ability to...
Unveiling the fate of lipid crystalline structures in engineered emulsions during in vitro digestion
This study investigates how lipid crystalline structures in emulsions evolve during digestion, aiming to inform functional food design and potentially modulate lipid digestion. Using synchrotron-based X-ray diffraction, we monitored real-time...
: Four novel gold(I) N-heterocyclic carbene (NHC) complexes were synthesized and characterized; they are tuned in terms of the aromatic extension of the NHC scaffold and two of them contain...
