Cyclooxygenase enzymes have distinct roles in cardiovascular,neurological, and neurodegenerative disease. They are differentlyexpressed in different type of cancers. Specific and selective COXsinhibitors are needed to be used alone or in...
The self-splicing group II introns are bacterial and organellar ancestors of the nuclear spliceosome and retro-transposable elements of pharmacological and biotechnological importance. Integrating enzymatic, crystallographic, and simulation studies, we demonstrate...
As the number of joint arthroplasties continues to increase, joint infections have emerged as a significant and devastating complication associated with total joint arthroplasty. The formation and persistence of bacterial...
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Accurate diagnosis of the preclinical stages of Alzheimer's disease (AD), by means of biomarker early detection, is considered crucial for therapeutic advancements. Current AD diagnosis relies on the combi- natorial...
Purpose: This paper aims to present a systematic review of the latest scientific literature, in the context of pediatric orthopedics, on the development by additive manufacturing of anatomical models, orthoses,...
In this work, we present three donor–acceptor thermally activated delayed fluorescence (TADF) molecules comprising a 2,3,5,6-tetrafluorobenzonitrile acceptor with various electron donor units: phenoxazine (Phx- BzN), phenothiazine (Pht-BzN), and carbazole (Cz-BzN)....
Organic thermoelectric materials are promisingfor wearable heating and cooling devices, as well as near-room-temperature energy generation, due to their nontoxicity,abundance, low cost, and flexibility. However, their primarychallenge preventing widespread use...
While the search for high-Tc superconductivity was driven mostly by trial and error methodology searching for novel materials, here we provide a quasi-first-principles quantum theory for engineering superconductivity in artificial...
: We have investigated the local structure of the iron-based CaKFe4As4superconductor featuring distinct aliovalent substitutions at the Ca and K sites, that is CaKFe4As4, CaK0.9Sr0.1Fe4As4, CaK0.9Ba0.1Fe4As4and Ca0.9Na0.1K0.9Ba0.1Fe4As4. Temperature-dependent Fe K-edge...
