Alzheimer's disease (AD) is a multifactorial pathology that requires multifaceted agents able to address its peculiar nature. Increasing evidence has shown that aggregation of amyloid ? (A?) and oxidative stress...
Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with protein-protein interactions, which are indispensable in bio-processes....
The difficulty to treat resistant strains-related hospital-acquired infections (HAIs) promoted the study of phytoextracts, known sources of bioactive molecules. Accordingly, in the present study, the pharmacological activities of Juglans regia...
The Nerve Growth Factor (NGF) neurotrophin acts in the maintenance and growth of neuronal populations. Despite the detailed knowledge of NGF's role in neuron physiology, the structural and mechanistic determinants...
Protein aggregation is suggested as a reversible, wide-spread physiological process used by cells to regulate their growth and adapt to different stress conditions. Nucleophosmin 1(NPM1) protein is an abundant multifunctional...
As mitochondria are vulnerable to oxidative damage and represent the main source of reactive oxygen species (ROS), they are considered key tuners of ROS metabolism and buffering, whose dysfunction can...
The high demand of hospitalization in the intensive care units (ICUs) during the first wave of the COVID-19 outbreak brought out the critical issues of the limited capacity of the...
Understanding the metal ion-protein interactions is crucial in transport, accumulation, and excretion of metals. Furthermore, it seems to be highly important to investigate the role of such complexes in many...
The major cause of bacterial resistance to ?-lactams is the production of hydrolytic ?-lac-tamase enzymes. Nowadays, the combination of ?-lactam antibiotics with ?-lactamase inhibitors (BLIs) is the main strategy for...
The scientific interest toward the structural, luminescence, and dielectric properties of tricalcium phosphate (TCP) materials, in particular, the doped TCP-based compounds, is mainly due to their biocompatibility and bioactivity behavior...
