In this article, the "Acknowledgments" section was missing the text below: Collaborations Pharmaceuticals Inc. acknowledges NIH funding: R44GM122196-02A1 from the National Institute of General Medical Sciences and 1R43ES031038-01 from the...
Several commercially available and newly synthesized riluzole analogs were evaluated in vitro as voltage-gated skeletal muscle sodium-channel blockers. Data obtained from the patch-clamp technique demonstrated that potency is well correlated...
A plethora of different electronic and optoelectronic devices have been developed lately, for biosensing applications (e.g., label-free, fast, and easier to operate) based on a detecting interface accommodating the biorecognition...
Following a hybridization strategy, a series of 5-substituted-1H-indazoles were designed and evaluated in vitro as inhibitors of human monoamine oxidase (hMAO) A and B. Among structural modifications, the bioisostere-based introduction...
The formal mechanism of linear mixed and non-competitive enzyme inhibition implies the binding ofinhibitors to both the active site of the free enzyme in competition with the substrate, and to...
Patterson superposition techniques are a historical method for solving the structures of small molecules ab initio, provided they contain heavy atoms in the unit cell. In the 1990s, they were...
A description of REMO22, a new molecular replacement program for proteins and nucleic acids, is provided. This program, as with REMO09, can use various types of prior information through appropriate...
We present the state of the art of the n_TOF Collaboration Working Group activity dedicated to study how to solve the puzzle about the existence of the so called new...
We examined the reaction of hydroxyl radicals (HOo) and sulfate radical anions (SO4o-), which is generated by ionizing radiation in aqueous solutions under anoxic conditions, with an alternating GC doubled-stranded...
Microcalcifications, small deposits of calcium-containing minerals that form in breast tissue, are often, but not always, a warning sign of breast cancer. The relationship between microcalcifications and cancer has not...
